Short Courses
Prior to Euroanalysis 16, several Short Courses will be organized:
- Applied Spectroscopy: Structure Elucidation of Organic Compounds (Full-day Course) CANCELLED
- Basics in Mass Spectrometry and Applications in the Pharmaceutical Industry (Full-day Course)
- Chemometrics in Excel – Interactive Educational Programme (Full-day Course)
- Role of Analytical Chemist in Pharmaceutical Research and Development (Half-day Course) CANCELLED
- Sample preparation (Half-day Course) CANCELLED
- Quality and Reliability in Analytical Chemistry (Half-day Course)
- Multivariate Resolution in Analytical Chemistry Chemometrics Course (Half-day Course) CANCELLED
All Short Courses begin on Sunday, September 11, 2011.
Basics in Mass Spectrometry and Applications in the Pharmaceutical Industry
(Full-day Course)
Course Description:
This course is for anyone seeking an introduction to the field of mass spectrometry, instrumentation, and applications in Pharmaceutical Industry (including proteomics, metabolomics, pharmacokinetics, and other techniques). A general understanding of a mass spectrometry is helpful but not required. Typical attendees include biologists, chemists, lab managers, marketing and sales professionals, and students. In addition to the basics of mass spec, case studies using mass spectrometry in Pfizer drug discovery teams as well as metobalomics efforts at Imperial College will be presented.
Course Topics:
- How mass spectrometers work (ion trap, quads, ToFs, FT-MS, hybrids)
- Ionization approaches for biological and chemical analysis
- Pharmacokinetics and methods for quantitation
- Metabolomics
- Basic Proteomics
- Dynamic structural characterization of proteins using HDX MS
- Protein identification and sequencing using MALDI-MS and LC/MS/MS
- Monitoring non-covalent interactions and bimolecular complexes using ESI-MS
- LC/MS and SFC/MS approaches and applications
Language: English
Course Instructors:
- Michael Greig (Michael.greig@pfizer.com) is an Associate Research Fellow and head of Project Analytical Sciences, a core biological mass spectrometry and NMR research group at Pfizer currently focusing on cancer research. Prior to that, he worked at Revlon Science Institute as a polymer and analytical chemist and was the Mass Spectrometry Lab Manager at Isis Pharmaceuticals. He has 20 years experience in the field of mass spectrometry and analytical chemistry, analyzing everything from small molecules to polymers to proteins. He has taught mass spectrometry classes at various scientific conferences around the world, was a Keynote speaker at the 2006 International Mass Spectrometry Conference, a member of the LabAutomation Scientific Committee for three years, current member of National High Magnetic Field Laboratory FT-ICR MS Advisory Panel, and has over 60 presentations and publications.
- Ben Bolanos is a Senior Principal Scientist in the Project Analytical Sciences group at Pfizer (La Jolla). He has over 15 years experience in the field of analytical chemistry, with a primary focus on mass spectrometry. He received his doctorate in analytical chemistry from the University of Texas in 1997, where his research focused on probing protein tertiary structure by electrospray/FT-ICR mass spectrometry. He was spent time in post-doctoral research position at The Rowland Institute at Harvard in 1998, where he was involved in the design of a quadrupole trap for studying non-covalent complexes. He has been with Pfizer for over 8 years, where he has operated an array of mass spectrometers for drug discovery and design applications. He was the Co-Chair of the Metabolomics workshop at the ASMS Conference for 2005-2006, and has contributed to numerous presentations and publications.
- Elizabeth Want is the Waters Lecturer in Molecular Spectroscopy in the Section of Biomolecular Medicine, Department of Surgery and Cancer, at Imperial College, London. Her research focuses primarily on the development and application of mass spectrometry-based metabolic profiling techniques to areas including toxicology and liver disease. Elizabeth has over 10 years experience in mass spectrometry. She obtained her PhD in Biochemistry and Clinical Endocrinology at King College London, where she studied steroid metabolism in the rat using GC-MS and LC-MS. She then undertook postdoctoral research in the Center for Mass Spectrometry at the Scripps Research Institute, La Jolla, where she was responsible for many of the initial metabolic profiling studies in this group. As a Sponsored Researcher at Pfizer Global R&D, La Jolla, she was again responsible for developing metabolic profiling approaches using LC-MS. Elizabeth joined Imperial College in 2006 as part of the Consortium for Metabonomic Toxicology (COMET), before being appointed to her current position of Lecturer in 2007. She has published >25 peer-reviewed articles and given numerous presentations in this field, at both national and international conferences. Elizabeth was co-organiser and presenter of the Metabolomics Short Course at ASMS for four years, and currently coordinates the annual Metabolic Profiling Short Course at Imperial College.
Chemometrics in Excel – Interactive Educational Programme
(Full-day course)
Course Description:
Chemometrics is a very practicable discipline. Therefore, in teaching chemometrics it is important not to explain the methods only, but to provide a student with a full access and ability to perform all relevant calculations as well. Not all universities have easy access to the special chemometric software packages. For this case a special Excel Chemometrics Add In have been designed.
The software implements the basic projection methods as the worksheet functions in Excel. All regular Excel capacities can be applied for additional data handling as well.
For additional course software description and for the latest updates, please, visit the course web-page http://rcs.chph.ras.ru/Tutorials/courses/euro2011/
Part 1 Introduction
Teaching of chemometrics in an interactive web-based mode
Presentation of the teaching materials
Main features of Chemometrics Add-In software
Special technique for matrix calculations in Excel (Excel.xls)
Computer exercises: basic Excel matrix calculations, regression, etc. Special tricks that provide a rapid and convenient processing of large data-sets in Excel (Task.xls; Tricks.xls)
Part 2 Advanced
- Overview of interactive material:
- Projection.xls
- Classification.xls
- MCR.xls
- Computer exercises: Calibration problem, comparison of different regression techniques using simulated data; detailed analysis and discussion (Calibration.xls)
- Computer exercise: Solving a real-world calibration problem – an example of chemometric assignment for students (DSC.xls)
Audience
The persons involved in teaching of chemometrics. A basic knowledge of chemometric concepts and methods, e.g., PCA and PLS is desirable.
Participants are encouraged to use their own laptops with Excel 2007
Course materials:
- Specially prepared xls-files as interactive teaching materials: Projection.xls, Classification.xls, Calibration.xls, MCR.xls
- Three web-orientated tutorials: Matrix calculations in Excel, Projection methods in Excel, Useful Formulae for Chemometrics Add-In, all accomplished with specially designed xls-files.
- Full individual license for Chemometrics Add-In software will be provided for all registered attendees.
Language: English
Course Instructors:
- DSc. Oxana Rodionova (ICP RAS, Moscow) http://rcs.chph.ras.ru/ICP/royeng.htm
Quality and Reliability in Analytical Chemistry
(Half-day course)
Course Description:
The goal of the analytical process is to obtain high quality information with high reliability. Although reliable analytical information implies quality, not all “quality” information proves reliable. The quality and reliability of samples, methods, instruments, and data processing will be highlighted. Also, there will be discussed sensitivity vs selectivity, uncertainty in chemical analysis, validation criteria for an analytical method, as well as method development in chemical analysis.
The course will help PhD and MSc students as well as young researchers to learn how to select de best analytical method for a certain sample, and how to validate the new developed method. The course will mainly be based on two books: HY Aboul-Enein, RI Stefan, GE Baiulescu “Quality and Reliability in Analytical Chemistry”, CRC Press, Boca Raton, Florida, USA, 2000, and DC Singer, RI Stefan, JF van Staden “Laboratory Auditing for Quality and Regulatory Compliance”, Taylor and Francis, Boca Raton, Florida, USA, 2005.
Language: English
Course Instructor:
- Prof Raluca-Ioana Stefan-van Staden (www.patlab.ro)
